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prof. dr. P.A.J.M. (Paul) Boon

Neuroloog Paul Boon vervult in Kempenhaeghe de rol van extern strategisch adviseur raad van bestuur op het vlak van wetenschappelijk onderzoek. Hij is een van de grondleggers en aanjagers van wetenschappelijk onderzoek in Kempenhaeghe. In die hoedanigheid leidt hij ook onderzoeksgroepen, wetenschappelijke projecten en ondersteunt hij jonge onderzoekers als promotor. Inhoudelijk richt Paul Boon zich met name op neuromodulatie en neuro-imaging.

Hij onderhoudt een breed netwerk en is een veel gevraagd spreker voor congressen in binnen- en buitenland. Naast zijn adviseurschap voor Kempenhaeghe werkt hij als neuroloog en diensthoofd Neurologie in het Universitair Ziekenhuis Gent. Ook is hij hoogleraar Neurologie aan de Universiteit Gent en bekleedt hij een leerstoel aan de Technische Universiteit Eindhoven. Daarnaast is Paul Boon sinds 2022 voorzitter van de European Academy of Neurology (EAN).

Aandachtsgebieden

  • Neuromodulatie (met name Deep Brain Stimulation)
  • Neuro-imaging
  • Pre-chirurgische evaluatie van patiënten met epilepsie
  • Klinische en experimentele epileptologie

Publicaties *

  • laatste 2 jaar, maandelijkse update

Neurostimulation for childhood epilepsy

Auteurs: Mertens A, Boon P, Vonck K
Reeks: Dev Med Child Neurol. 2023 Jul 14. doi: 10.1111/dmcn.15692. Epub ahead of print
Datum: 14-07-2023
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Decreasing incidence of stroke, ischemic heart disease and dementia in Norway, 1990-2019, a Global Burden of Disease Study: An Opportunity

Auteurs: Avan A, Aamodt AH, Selbaek G, Bovim G, Bassetti CLA, Boon P, Grisold W, Hachinski V
Reeks: Eur J Neurol. 2023 Aug;30(8):2267-2277. doi: 10.1111/ene.15836. Epub 2023 May 21
Datum: 08-05-2023
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Deep Brain Stimulation of the Anterior Nucleus of the Thalamus in Drug Resistant Epilepsy in the MORE Multicenter Patient Registry

Auteurs: Peltola J, Colon AJ, Pimentel J, Coenen VA, Gil-Nagel A, Ferreira AG, Lehtim�ki K, Ryvlin P, Taylor RS, Ackermans L, Ardesch J, Bentes C, Bosak M, Burneo JG, Chamadoira C, Elger CE, Er?ss L, Fabo D, Faulkner H, Gawlowicz J, Gharabaghi A, Iacoangeli M, Janszky J, J�rvenp�� S, Kaufmann E, Kho KH, Kumlien E, Laufs H, Lettieri C, Linhares P, Noachtar S, Parrent A, Pataraia E, Patel NK, Peralta AR, R�cz A, Campos AR, Rego R, Ricciuti RA, Rona S, Rouhl RPW, Schulze-Bonhage A, Schuurman R, Sprengers M, Sufianov A, Temel Y, Theys T, Van Paesschen W, Van Roost D, Vaz R, Vonck K, Wagner L, Zwemmer J, Abouihia A, Brionne TC, Gielen F, Boon PAJM.
Reeks: Neurology. 2023 Mar 16:10.1212/WNL.0000000000206887. doi: 10.1212/WNL.0000000000206887. Epub ahead of print
Datum: 16-03-2023
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Seizure-related complication rate in a residential population with epilepsy and intellectual disability (ECOMRAID-trial)

Auteurs: Monte CPJA, Arends JBAM, Lazeron RHC, Tan IY, Boon PAJM
Reeks: Epilepsy Behav. 2023 Mar;140:108995. doi: 10.1016/j.yebeh.2022.108995. Epub 2023 Feb 21.
Datum: 21-02-2023
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Translational veterinary epilepsy: A win-win situation for human and veterinary neurology

Auteurs: Charalambous M, Fischer A, Potschka H, Walker MC, Raedt R, Vonck K, Boon P, Lohi H, L�scher W, Worrell G, Leeb T, McEvoy A, Striano P, Kluger G, Galanopoulou AS, Volk HA, Bhatti SFM
Reeks: Vet J. 2023 Mar;293:105956. doi: 10.1016/j.tvjl.2023.105956. Epub 2023 Feb 13.
Datum: 13-02-2023
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Epilepsy-Related Direct Medical and Direct Non-Medical Cost in Adult Patients Living with Epilepsy at a Tertiary Neurology Center in Rwanda

Auteurs: Teuwen DE, Sebera F, Murekeyiteto A, Garrez I, Sanchez-Iriso E, Umwiringirwa J, Umuhoza G, Boon PAJM, Dedeken P
Reeks: Clinicoecon Outcomes Res. 2023 Jan 11;15:15-27. doi: 10.2147/CEOR.S382030
Datum: 11-01-2023
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Association of depression and epilepsy in Rwanda: A prospective longitudinal study.

Auteurs: Sebera F, Dedeken P, Garrez I, Umwiringirwa J, Leers T, Ndacyayisenga JP, Mutungirehe S, Ndayisenga A, Niyonzima O, Umuhoza G, Teuwen DE, Boon PAMJ.
Reeks: Epilepsy Behav. 2023 Jan;138:108993. doi: 10.1016/j.yebeh.2022.108993. Epub 2022 Nov 28
Datum: 10-01-2023
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In vivo inhibition of epileptiform afterdischarges in rat hippocampus by light-activated chloride channel, stGtACR2

Auteurs: Acharya AR, Larsen LE, Delbeke J, Wadman WJ, Vonck K, Meurs A, Boon P, Raedt R
Reeks: CNS Neurosci Ther. 2022 Dec 8. doi: 10.1111/cns.14029. Epub ahead of print
Datum: 08-12-2022
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Cognitive tasks propagate the neural entrainment in response to a visual 40 Hz stimulation in humans.

Auteurs: Khachatryan E, Wittevrongel B, Reinartz M, Dauwe I, Carrette E, Meurs A, Van Roost D, Boon P, Van Hulle MM
Reeks: Front Aging Neurosci. 2022 Oct 6;14:1010765. doi: 10.3389/fnagi.2022.1010765
Datum: 06-10-2022
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Continuous theta burst stimulation for drug-resistant epilepsy.

Auteurs: Carrette S, Boon P, Klooster D, Van Dycke A, Carrette E, Miatton M, Raedt R, Delbeke J, Meurs A, Vonck K.
Reeks: Front Neurosci. 2022 Aug 17;16:885905. doi: 10.3389/fnins.2022.885905
Datum: 17-08-2022
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Ex Vivo Feedback Control of Neurotransmission Using a Photocaged Adenosine A1 Receptor Agonist

Auteurs: Craey E, Hulpia F, Spanoghe J, Manzella S, Larsen LE, Sprengers M, De Bundel D, Smolders I, Carrette E, Delbeke J, Vonck K, Boon P, Van Calenbergh S, Wadman WJ, Raedt R
Reeks: Int J Mol Sci. 2022 Aug 10;23(16):8887. doi: 10.3390/ijms23168887
Datum: 10-08-2022
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The European Academy of Neurology Brain Health Strategy: One brain, one life, one approach

Auteurs: Bassetti CLA, Endres M, Sander A, Crean M, Subramaniam S, Carvalho V, Di Liberto G, Franco OH, Pijnenburg Y, Leonardi M, Boon P.
Reeks: Eur J Neurol. 2022 Sep;29(9):2559-2566. doi: 10.1111/ene.15391. Epub 2022 Jun 21
Datum: 21-06-2022
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Recent Advances in the Use of Focused Ultrasound as a Treatment for Epilepsy

Auteurs: Lescrauwaet E, Vonck K, Sprengers M, Raedt R, Klooster D, Carrette E, Boon P
Reeks: Front Neurosci. 2022 Jun 20;16:886584. doi: 10.3389/fnins.2022.886584
Datum: 20-06-2022
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The EAN Brain Health Strategy: One Brain, One Life, One Approach

Auteurs: Bassetti CLA, Endres M, Sander A, Crean M, Subramaniam S, Carvalho V, Di Liberto G, Franco OH, Pijnenburg Y, Leonardi M, Boon P
Reeks: Eur J Neurol. 2022 May 10. doi: 10.1111/ene.15391. Epub ahead of print
Datum: 10-05-2022
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Personalized tDCS for Focal Epilepsy-A Narrative Review: A Data-Driven Workflow Based on Imaging and EEG Data

Auteurs: Beumer S, Boon P, Klooster DCW, van Ee R, Carrette E, Paulides MM, Mestrom RMC
Reeks: Brain Sci. 2022 May 7;12(5):610. doi: 10.3390/brainsci12050610
Datum: 07-05-2022
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mBrain: towards the continuous follow-up and headache classification of primary headache disorder patients

Auteurs: De Brouwer M, Vandenbussche N, Steenwinckel B, Stojchevska M, Van Der Donckt J, Degraeve V, Vaneessen J, De Turck F, Volckaert B, Boon P, Paemeleire K, Van Hoecke S, Ongenae F
Reeks: BMC Med Inform Decis Mak. 2022 Mar 31;22(1):87. doi: 10.1186/s12911-022-01813-w
Datum: 31-03-2022
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Laryngeal Muscle-Evoked Potential Recording as an Indicator of Vagal Nerve Fiber Activation

Auteurs: Bouckaert C, Raedt R, Larsen LE, El Tahry R, Gadeyne S, Carrette E, Proesmans S, Dewaele F, Delbeke J, De Herdt V, Meurs A, Mertens A, Boon P, Vonck K
Reeks: Neuromodulation. 2022 Apr;25(3):461-470. doi: 10.1016/j.neurom.2022.01.014. Epub 2022 Feb 15
Datum: 14-02-2022
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The potential of invasive and non-invasive vagus nerve stimulation to improve verbal memory performance in epilepsy patients

Auteurs: Mertens A, Gadeyne S, Lescrauwaet E, Carrette E, Meurs A, De Herdt V, Dewaele F, Raedt R, Miatton M, Boon P, Vonck K.
Reeks: Sci Rep. 2022 Feb 7;12(1):1984. doi: 10.1038/s41598-022-05842-3
Datum: 07-02-2022
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Transcutaneous auricular vagus nerve stimulation cannot modulate the P3b event-related potential in healthy volunteers

Auteurs: Gadeyne S, Mertens A, Carrette E, Van den Bossche F, Boon P, Raedt R, Vonck K.
Reeks: Clin Neurophysiol. 2021 Dec 29;135:22-29. doi: 10.1016/j.clinph.2021.11.079. Epub ahead of print.
Datum: 29-12-2021
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In vivoblue light illumination for optogenetic inhibition: effect on local temperature and excitability of the rat hippocampus

Auteurs: Acharya AR, Vandekerckhove B, Larsen LE, Delbeke J, Wadman WJ, Vonck K, Carette E, Meurs A, Vanfleteren J, Boon P, Missinne J, Raedt R
Reeks: J Neural Eng. 2021 Dec 24;18(6). doi: 10.1088/1741-2552/ac3ef4
Datum: 24-12-2021
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Chemogenetic Seizure Control with Clozapine and the Novel Ligand JHU37160 Outperforms the Effects of Levetiracetam in the Intrahippocampal Kainic Acid Mouse Model.

Auteurs: Desloovere J, Boon P, Larsen LE, Goossens MG, Delbeke J, Carrette E, Wadman W, Vonck K, Raedt R.
Reeks: Neurotherapeutics. 2021 Dec 3. doi: 10.1007/s13311-021-01160-0. Epub ahead of print
Datum: 03-12-2021
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Qualitative exploration of feasibility and acceptability of the modified ketogenic dietary therapy for children with drug-resistant epilepsy in Kenya.

Auteurs: Samia P, Naanyu V, Cross JH, Idro R, Boon P, Wilmshurst J, Luchters S
Reeks: Epilepsy Behav. 2021 Nov 2;125:108362. doi: 10.1016/j.yebeh.2021.108362. Epub ahead of print.
Datum: 02-11-2021
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Voxel-Based Analysis of [18F]-FDG Brain PET in Rats Using Data-Driven Normalization

Auteurs: Proesmans S, Raedt R, Germonpré C, Christiaen E, Descamps B, Boon P, De Herdt V, Vanhove C.
Reeks: Front Med (Lausanne). 2021 Oct 20;8:744157. doi: 10.3389/fmed.2021.744157
Datum: 20-10-2021
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Severe autonomic nervous system imbalance in Lennox-Gastaut syndrome patients demonstrated by heart rate variability recordings

Auteurs: Hödl S, Olbert E, Mahringer C, Carrette E, Meurs A, Gadeyne S, Dauwe I, Goossens L, Raedt R, Boon P, Vonck K
Reeks: Epilepsy Res. 2021 Oct 5;177:106783. doi: 10.1016/j.eplepsyres.2021.106783. Epub ahead of print
Datum: 05-10-2021
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Level of hM4D(Gi) DREADD expression determines inhibitory and neurotoxic effects in the hippocampus

Auteurs: Goossens MG, Larsen LE, Vergaelen M, Wadman W, Van den Haute C, Brackx W, Proesmans S, Desloovere J, Christiaen E, Craey E, Vanhove C, Vonck K, Boon P, Raedt R
Reeks: eNeuro. 2021 Oct 5:ENEURO.0105-21.2021. doi: 10.1523/ENEURO.0105-21.2021. Epub ahead of print.
Datum: 05-10-2021
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Comparison of In Vivo and Ex Vivo Magnetic Resonance Imaging in a Rat Model for Glioblastoma-Associated Epilepsy

Auteurs: Bouckaert C, Christiaen E, Verhoeven J, Descamps B, De Meulenaere V, Boon P, Carrette E, Vonck K, Vanhove C, Raedt R
Reeks: Diagnostics (Basel). 2021 Jul 21;11(8):1311. doi: 10.3390/diagnostics11081311
Datum: 21-07-2021
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Investigating the Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Cortical Excitability in Healthy Males

Auteurs: Mertens A, Carrette S, Klooster D, Lescrauwaet E, Delbeke J, Wadman WJ, Carrette E, Raedt R, Boon P, Vonck K.
Reeks: Neuromodulation. 2021 Jul 20. doi: 10.1111/ner.13488. Epub ahead of print
Datum: 20-07-2021
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White matter integrity in a rat model of epileptogenesis: structural connectomics and fixel-based analysis

Auteurs: Christiaen E, Goossens MG, Descamps B, Delbeke J, Wadman W, Vonck K, Boon P, Raedt R, Vanhove C
Reeks: Brain Connect. 2021 Jun 22. doi: 10.1089/brain.2021.0026. Epub ahead of print
Datum: 22-06-2021
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Seizures and Interictal Epileptiform Activity in the Rat Collagenase Model for Intracerebral Hemorrhage

Auteurs: Germonpr� C, Proesmans S, Bouckaert C, Sprengers M, Boon P, Raedt R, De Herdt V
Reeks: Front Neurosci. 2021 Jun 18;15:682036. doi: 10.3389/fnins.2021.682036
Datum: 18-06-2021
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Optimized Parameters for Transducing the Locus Coeruleus Using Canine Adenovirus Type 2 (CAV2) Vector in Rats for Chemogenetic Modulation Research

Auteurs: Stevens L, Larsen LE, Van Lysebettens W, Carrette E, Boon P, Raedt R, Vonck K
Reeks: Front Neurosci. 2021 Apr 13;15:663337. doi: 10.3389/fnins.2021.663337
Datum: 13-04-2021
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Hippocampal Sclerosis in Frontotemporal Dementia: When Vascular Pathology Meets Neurodegeneration

Auteurs: Sieben A, Van Langenhove T, Vermeiren Y, Gossye H, Praet M, Vanhauwaert D, Cousaert C, Engelborghs S, Raedt R, Boon P, Santens P, De Deyn PP, Bracke KR, De Meulemeester K, Van Broeckhoven C, Martin JJ, Bjerke M
Reeks: J Neuropathol Exp Neurol. 2021 Feb 26:nlab010. doi: 10.1093/jnen/nlab010. Epub ahead of print
Datum: 26-02-2021
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Long-term chemogenetic suppression of seizures in a multifocal rat model of temporal lobe epilepsy

Auteurs: Goossens MG, Boon P, Wadman W, Van den Haute C, Baekelandt V, Verstraete AG, Vonck K, Larsen LE, Sprengers M, Carrette E, Desloovere J, Meurs A, Delbeke J, Vanhove C, Raedt R
Reeks: Epilepsia. 2021 Feb 11. doi: 10.1111/epi.16840. Epub ahead of print.
Datum: 11-02-2021
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Pre-ictal heart rate variability alterations in focal onset seizures and response to vagus nerve stimulation

Auteurs: Hödl S, Olbert E, Mahringer C, Struhal W, Carrette E, Meurs A, Gadeyne S, Dauwe I, Goossens L, Raedt R, Boon P, Vonck K
Reeks: Seizure. 2021 Feb 17;86:175-180. doi: 10.1016/j.seizure.2021.02.017. Epub ahead of print
Datum: 07-02-2021
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Technological Challenges in the Development of Optogenetic Closed-Loop Therapy Approaches in Epilepsy and Related Network Disorders of the Brain.

Auteurs: Vandekerckhove B, Missinne J, Vonck K, Bauwens P, Verplancke R, Boon P, Raedt R, Vanfleteren J
Reeks: Micromachines (Basel). 2020 Dec 31;12(1):38. doi: 10.3390/mi12010038
Datum: 31-12-2020
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The Signaling Pathways Involved in the Anticonvulsive Effects of the Adenosine A1 Receptor.

Auteurs: Spanoghe J, Larsen LE, Craey E, Manzella S, Van Dycke A, Boon P, Raedt R
Reeks: Int J Mol Sci. 2020 Dec 30;22(1):320. doi: 10.3390/ijms22010320
Datum: 30-12-2020
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Alterations in the functional brain network in a rat model of epileptogenesis: A longitudinal resting state fMRI study

Auteurs: Christiaen E, Goossens MG, Raedt R, Descamps B, Larsen LE, Craey E, Carrette E, Vonck K, Boon P, Vanhove C
Reeks: Neuroimage. 2019 Nov 15;202:116144. doi: 10.1016/j.neuroimage.2019.116144. Epub 2019 Aug 29
Datum: 15-11-2020
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Recommendations for the treatment of epilepsy in adult and pediatric patients in Belgium: 2020 update

Auteurs: Boon P, Ferrao Santos S, Jansen AC, Lagae L, Legros B, Weckhuysen S.
Reeks: Acta Neurol Belg. 2020 Oct 13. doi: 10.1007/s13760-020-01488-y. Epub ahead of print
Datum: 13-10-2020
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European Expert Opinion on ANT-DBS therapy for patients with drug-resistant epilepsy (a Delphi consensus).

Auteurs: Kaufmann E, Bartolomei F, Boon P, Chabardes S, Colon AJ, Eross L, Fabó D, Gonçalves-Ferreira A, Imbach LL, Van Paesschen W, Peltola J, Rego R, Theys T, Voges B
Reeks: Seizure. 2020 Oct;81:201-209. doi: 10.1016/j.seizure.2020.08.015. Epub 2020 Aug 22
Datum: 01-10-2020
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Development of a Rat Model for Glioma-Related Epilepsy

Auteurs: Bouckaert C, Germonpré C, Verhoeven J, Chong SA, Jacquin L, Mairet-Coello G, André VM, Leclercq K, Vanhove C, De Vos F, Van den Broecke C, Goethals I, Descamps B, Donche S, Carrette E, Wadman W, Boon P, Vonck K, Raedt R
Reeks: Int J Mol Sci. 2020 Sep 23;21(19):E6999. doi: 10.3390/ijms21196999.
Datum: 23-09-2020
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Localization of deep brain activity with scalp and subdural EEG

Auteurs: Fahimi Hnazaee M, Wittevrongel B, Khachatryan E, Libert A, Carrette E, Dauwe I, Meurs A, Boon P, Van Roost D, Van Hulle MM
Reeks: Neuroimage. 2020 Sep 6;223:117344. doi: 10.1016/j.neuroimage.2020.117344. Epub ahead of print
Datum: 06-09-2020
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High-gamma oscillations precede visual steady-state responses: A human electrocorticography study.

Auteurs: Wittevrongel B, Khachatryan E, Carrette E, Boon P, Meurs A, Van Roost D, Van Hulle MM
Reeks: Hum Brain Mapp. 2020 Sep 4. doi: 10.1002/hbm.25196. Epub ahead of print.
Datum: 04-09-2020
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Deep Brain Stimulation in Epilepsy: A Role for Modulation of the Mammillothalamic Tract in Seizure Control?

Auteurs: Schaper FLWVJ, Plantinga BR, Colon AJ, Wagner GL, Boon P, Blom N, Gommer ED, Hoogland G, Ackermans L, Rouhl RPW, Temel Y.
Reeks: Neurosurgery. 2020 Sep 1;87(3):602-610. doi: 10.1093/neuros/nyaa141
Datum: 01-09-2020
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Mortality of all causes and sudden unexplained death in epilepsy (SUDEP) in a cohort of 235 persons living with epilepsy in Rwanda using WHO Verbal Autopsy Questionnaire

Auteurs: Sebera F, Uwacu BH, Nsanzabaganwa W, Umwiringirwa J, Dedeken P, Teuwen DE, Boon PAJM
Reeks: Epilepsy Behav Rep. 2020 Jul 30;14:100383. doi: 10.1016/j.ebr.2020.100383
Datum: 30-07-2020
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Identification of vagus nerve stimulation parameters affecting rat hippocampal electrophysiology without temperature effects

Auteurs: Van Lysebettens W, Vonck K, Larsen LE, Stevens L, Bouckaert C, Germonpré C, Sprengers M, Carrette E, Delbeke J, Wadman WJ, Boon P, Raedt R
Reeks: Brain Stimul. 2020 Sep-Oct;13(5):1198-1206. doi: 10.1016/j.brs.2020.05.011
Datum: 23-05-2020
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A Feasibility Study to Investigate Chemogenetic Modulation of the Locus Coeruleus by Means of Single Unit Activity.

Auteurs: Stevens L, Vonck K, Larsen LE, Van Lysebettens W, Germonpré C, Baekelandt V, Van den Haute C, Carrette E, Wadman WJ, Boon P, Raedt R
Reeks: Front Neurosci. 2020 Mar 6;14:162. doi: 10.3389/fnins.2020.00162
Datum: 06-03-2020
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Novel therapies for epilepsy in the pipeline

Auteurs: Mesraoua B, Deleu D, Kullmann DM, Shetty AK, Boon P, Perucca E, Mikati MA, Asadi-Pooya AA
Reeks: Epilepsy Behav. 2019 Jul 5;97:282-290. doi: 10.1016/j.yebeh.2019.04.042. [Epub ahead of print]
Datum: 05-07-2019
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Single-Cell Recordings to Target the Anterior Nucleus of the Thalamus in Deep Brain Stimulation for Patients with Refractory Epilepsy.

Auteurs: Schaper FLWVJ, Zhao Y, Janssen MLF, Wagner GL, Colon AJ, Hilkman DMW, Gommer E, Vlooswijk MCG, Hoogland G, Ackermans L, Bour LJ, Van Wezel RJA, Boon P, Temel Y, Heida T, Van Kranen-Mastenbroek VHJM, Rouhl RPW.
Reeks: Int J Neural Syst. 2019 May;29(4):1850012. doi: 10.1142/S0129065718500120. Epub 2018 Apr 2.
Datum: 01-05-2019
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Focal application of accelerated iTBS results in global changes in graph measures.

Auteurs: Klooster DCW, Franklin SL, Besseling RMH, Jansen JFA, Caeyenberghs K, Duprat R, Aldenkamp AP, de Louw AJA, Boon PAJM, Baeken C.
Reeks: Hum Brain Mapp. 2019 Feb 1;40(2):432-450. doi: 10.1002/hbm.24384. Epub 2018 Oct 1.
Datum: 01-02-2019
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Epileptic seizures associated with syncope

Auteurs: Monté CP, Monté CJ, Boon P, Arends J.
Reeks: Epilepsy Behav. 2019 Jan;90:168-171. doi: 10.1016/j.yebeh.2018.10.027. Epub 2018 Dec 19. Review.
Datum: 08-01-2019
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